Coumarin is broadly used as Anti inflammatory, Blood-thinning, Anti-fungicidal and Anti-tumor agent. To optimize the dissolution procedure, various trials have been done with different pH and stirring speeds like 50, 75 and 100 rpm. The samples were withdrawn at various time intervals and analyzed by UV spectrophotometric method at 277 nm. The analytical method was validated for accuracy, precision and recovery studies. Statistical analysis proved that the method was precise, reproducible, selective, specific, and accurate for the analysis of coumarin. The discriminating power of the selected dissolution procedure relative to other dissolution procedure was evaluated. From the observed results, the use of the phosphate buffer pH 6.8 (900mL, at 37 ± 0.5ºC) as dissolution medium, paddle method (Apparatus Type II), stirring speed of the dissolution medium at 75 rpm for 45 min can be the appropriate procedure for performing the dissolution studies of coumarin in the tablet pharmaceutical dosage form.
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